Lubbers R, van Essen MF, van Kooten C et al.
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Clinical and experimental immunology. Mar 2017.
The complement system is an important part of the innate immune defence. It not only contributes to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste disposal and developmental programs. The complement system comprises several soluble and membrane bound proteins. The bulk of the soluble proteins is mainly produced by the liver. While several complement proteins are produced by a wide variety of cell types other complement proteins are produced by only a few related cell types. Since these data suggest that local production by specific cell types may have specific functions, more detailed studies have recently been employed analysing the local and even intra-cellular role of these complement proteins. Here we review the current knowledge about extra-hepatic production and/or secretion of complement components. More specifically we address what is known about complement synthesis by cells of the human immune system. This article is protected by copyright. All rights reserved.