Large population study shows that adolescents with celiac disease have an increased risk of multiple autoimmune and non-autoimmune comorbidities.

Assa A, Frenkel-Nir Y, Tzur D et al.

Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children’s Medical center, 14 Kaplan st., Petach Tikva, Israel, 4920235.

Acta paediatrica (Oslo, Norway : 1992). Mar 2017.

Celiac disease (CD) is a systemic disorder that is associated with various autoimmune disorders and a higher prevalence of other diagnoses and complications. This large, cross-sectional, population-based study investigated the associations between CD and various medical conditions during late adolescence.We included 2,001,353 Jewish Israeli adolescents who underwent a general health examination at a median age of 17.1 (16.9-17.4) years from 1988-2015. Comprehensive data regarding medical status were available for 1,588,041 (79%) subjects. A definite diagnosis of CD was based on accepted criteria. Covariate data included demographic measures and data on associated medical conditions.Overall, data on 7,145 subjects with CD and 1,580,896 controls were analysed. Multivariate analyses showed that autoimmune diseases were significantly more common in subjects with CD, including insulin dependent diabetes, with an odds ratio (OR) of 5.5, inflammatory bowel diseases (OR=3.8), arthritis (OR=2.4), thyroid diseases (OR=1.8), and psoriatic skin disorders (OR=1.6). Further associations included asthma (OR=1.5), bile stones (OR=3.6), migraine (OR=2.3), anaemia (OR=1.7) and menstrual abnormalities (OR=1.5). Long bone fractures and axial fractures were no more common in adolescents with CD than controls.CD was already associated with multiple comorbidities by adolescence and these were not limited to autoimmune disorders. This article is protected by copyright. All rights reserved.


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