The independent predictors of significant liver histological changes in chronic hepatitis B virus infection patients with persistently high-normal or low-normal alanine transaminase levels.

Li Q, Lu C, Li W et al.

Department of Hepatitis, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200032, China.

Discovery medicine. Jan 2017.

To determine the independent predictors of significant liver histological changes (SLHC) defined as inflammatory grade ≥A2 and/or fibrosis stage ≥F2 using the METAVIR scoring system in chronic hepatitis B virus (HBV) infection patients with persistently normal ALT (PNALT) levels.We enrolled 392 chronic HBV infection patients with PNALT defined as normal ALT (≤40 IU/L) measured on at least three occasions at intervals of more than 2 months apart over a period of 12 or more months. Univariate and multiple analyses were performed to identify the independent predictors of SLHC in high-normal ALT (HNALT) (20Pubmed

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