Normothermic Machine Perfusion: A new world deserving careful exploration.

Pezzati D, Liu Q, Hassan A et al.

Cleveland Clinic Lerner College of Medicine, Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Feb 2017.

We read with interest the manuscript "Preliminary Single Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Result of a Clinical Trial" by Bral and colleagues. (1) The Authors compared their experience transplanting 10 livers using normothermic machine perfusion (NMP) to 30 historic controls matched by on five different characteristics. The primary objective of the study was to "assess safety of NMP in continuous liver preservation". No statistically significant differences were detected in 30-day patient survival (primary outcome). Among the secondary outcomes, only Intensive Care Unit (ICU) and hospital stay were statistically significantly more prolonged in the NMP group. One graft was lost because of technical problems during perfusion. We congratulate the Authors for their innovative endeavor on a technology that holds the potential to revolutionize the field of organ preservation . This article is protected by copyright. All rights reserved.


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