Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism.

De Cosmo S, Mazzoccoli G, et al.

Department of Medical Sciences, Division of Internal Medicine and Chronobiology Unit, IRCCS "Ospedale Casa Sollievo della Sofferenza" , San Giovanni Rotondo , Italy.

Frontiers in endocrinology. 2017.

Liver metabolic pathways are driven by the biological clock, and appropriate timing of 24-h patterns of metabolic gene expression as well as anabolic/catabolic processes with wake-related activity/feeding and sleep-related resting/fasting cycles preserves hepatic healthiness. The interplay among the liver metabolic pathways and the molecular clockwork is geared by the nuclear receptors, and ligand-dependent transcription factors that gauge the cellular nutritional status and redox balance, bind hormones and metabolites, and modulate the transcription of thousands target genes through their DNA-binding domain. Several nuclear receptors in the liver oscillate with circadian rhythmicity, and among these, the retinoid X receptors play a key role in metabolism regulation, intersecting with the cogs of the molecular clockwork.


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