Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells.

 

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Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells.

Biol Chem. 2015 Sep 2;

Authors: Groll N, Kollotzek F, Goepfert J, Joos TO, Schwarz M, Braeuning A

Abstract
The antiepileptic drug phenobarbital (PB) exerts hepatic effects related to cell proliferation and tumorigenesis which are closely linked to the Wnt/β-catenin signaling pathway. This pathway is, amongst others, regulated by calpain proteases. We now identified PB as an inhibitor of Wnt/β-catenin signaling in mouse hepatoma cells. Further analyses revealed that PB inhibits calpain activity, an effect which is at least in parts mediated by a transcriptional regulation of calpain mRNA levels and which is furthermore independent of the constitutive androstane receptor, the known mediator of most effects of PB in liver cells.

PMID: 26351921 [PubMed – as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26351921?dopt=Abstract

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