Liver transplantation for fulminant genotype 2a/c hepatitis C virus marked by a rapid recurrence followed by cure.

Tracy B, Shrestha R, Stein L et al.

Department of Surgery, Memorial University Medical Center, Savannah, GA, USA.

Transplant infectious disease : an official journal of the Transplantation Society. Mar 2017.

Although chronic hepatitis C is still the leading indication for liver transplantation (LT) in the United States and Europe, acute liver failure caused by to hepatitis C is distinctly uncommon and transplantation for fulminant hepatitis C virus (HCV) has not been documented in the United States. We present a case report of fulminant hepatic failure caused by genotype 2a/c HCV not only treated with LT, but also complicated by severe, rapid recurrence of HCV within 6 days of transplantation. The risk factor for the infection was likely sexual, as there were no other concomitant causes of liver disease pre-transplant or explanations for acute hepatitis post-transplant. Treatment with all-oral direct antiviral agents was swiftly initiated during the index hospitalization, leading to resolution of the acute hepatitis and resulting in sustained virologic response. It can only be speculated whether this was an infection with the JFH-1 strain or another similarly virulent genotype 2a/c HCV infection. This article is protected by copyright. All rights reserved.

Pubmed

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