Emerging pharmacologic therapies for primary sclerosing cholangitis.

Cheung AC, Lazaridis KN, LaRusso NF et al.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Current opinion in gastroenterology. Mar 2017.

The only currently approved treatment for primary sclerosing cholangitis (PSC) is liver transplantation, with a median time to transplant of 12-18 years after diagnosis. There are a number of emerging drugs that have the potential to meet this critically unmet need that will be summarized and discussed herein.Although the cause of PSC is unknown, there are a number of novel therapeutics under development. These drugs target presumed pathogenic mechanisms largely extrapolated from ex-vivo and in-vivo preclinical models, as well as translational observations.Future therapeutic strategies for PSC may include a multitude of complex pathogenic mechanisms encompassing pathways of immunomodulation, the microbiome and inflammation-related fibrosis.

Pubmed

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