[Recent advances in miR-200c and fibrosis in organs].

Chen J, Cai J, Du C et al.

Department of Periodontics, Xiangya Stomatological Hospital, Central South University, Changsha 410078, China.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. Feb 2017.

In the fibrosis and pterygium of lung, liver, kidney, peritoneum or skin, miR-200c was aberrantly expressed. It has been shown that the regulatory effect of miR-200c on fibrosis in organ was involved in TGF-β-mediated epithelial-mesenchymal transition. The abnormal level of miR-200c in serum may be a basis for early diagnosis of lung fibrosis. Furthermore, miRNA mimics, miRNA agomir, and miRNA inhibitor are potential therapeutic tools for fibrosis. In present review, we summarize the recent progress in relevant studies on the expression and regulatory function of miR-200c and focus on its role in diagnosis, treatment, and prognosis of fibrosis in organ.


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