Briones-Orta MA, Eréndira Avendaño-Vázquez S, Aparicio-Bautista DI et al.
Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, United Kingdom.
Biochimica et biophysica acta. Feb 2017.
Osteopontin (OPN) is an extracellular matrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival, migration, and angiogenesis, among others. OPN can participate in the regulation of the tumor microenvironment, affecting both cancer and neighboring cells. Here, we reviewed the roles of OPN splice variants (a, b, c) in cancer development, progression, and prognosis, and also discussed the identities of isoforms 4 and 5. We also discussed how single-nucleotide polymorphisms (SNPs) of the OPN gene are an additional factor influencing the level of OPN in individuals, modulating the risks of cancer development and outcome.