Systemic Regulators of Skeletal Muscle Regeneration in Obesity.

Sinha I, Sakthivel D, Varon DE et al.

Division of Plastic Surgery, Brigham and Women’s Hospital , Boston, MA , USA.

Frontiers in endocrinology. 2017.

Skeletal muscle maintenance is a dynamic process and undergoes constant repair and regeneration. However, skeletal muscle regenerative capacity declines in obesity. In this review, we focus on obesity-associated changes in inflammation, metabolism, and impaired insulin signaling, which are pathologically dysregulated and ultimately result in a loss of muscle mass and function. In addition, we examine the relationships between skeletal muscle, liver, and visceral adipose tissue in an obese state.